Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a key enzyme in conversion of glutamine to glutamate, and thereby a regulator of glutathione (GSH) synthesis and energy production. GLS2 expression is induced in response to DNA damage or oxidative stress in a p53...

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Main Authors: Suzuki, Sawako, Tanaka, Tomoaki, Poyurovsky, Masha V., Nagano, Hidekazu, Mayama, Takafumi, Ohkubo, Shuichi, Lokshin, Maria, Hosokawa, Hiroyuki, Nakayama, Toshinori, Suzuki, Yutaka, Sugano, Sumio, Sato, Eiichi, Nagao, Toshitaka, Yokote, Koutaro, Tatsuno, Ichiro, Prives, Carol
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867754/
https://ncbi.nlm.nih.gov/pubmed/20351271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002459107
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