Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds

The broadly neutralizing antibody 2G12 recognizes a conserved cluster of high mannose glycans on the surface envelope spike of HIV suggesting that the “glycan shield” defense of the virus can be breached and may, under the right circumstances, serve as a vaccine target. In an attempt to recreate fea...

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Detalhes bibliográficos
Main Authors: Astronomo, Rena D., Kaltgrad, Eiton, Udit, Andrew K., Wang, Sheng-Kai, Doores, Katie J., Huang, Cheng-Yuan, Pantophlet, Ralph, Paulson, James C., Wong, Chi-Huey, Finn, M.G., Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867452/
https://ncbi.nlm.nih.gov/pubmed/20416507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.03.012
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