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IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression

Congestive heart failure is associated with activation of the renin-angiotensin system and skeletal muscle wasting. Angiotensin II (ANG II) has been shown to increase muscle proteolysis and decrease circulating and skeletal muscle IGF-1. We have shown previously that skeletal muscle-specific overexp...

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Main Authors: Yoshida, Tadashi, Semprun-Prieto, Laura, Sukhanov, Sergiy, Delafontaine, Patrice
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867436/
https://ncbi.nlm.nih.gov/pubmed/20228261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00146.2010
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