Co-receptor choice by Vα14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection

Mouse natural killer T (NKT) cells with an invariant Vα14-Jα18 rearrangement (Vα14 invariant [Vα14i] NKT cells) are either CD4(+)CD8(−) or CD4(−)CD8(−). Because transgenic mice with forced CD8 expression in all T cells exhibited a profound NKT cell deficit, the absence of CD8 has been attributed to...

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Main Authors: Engel, Isaac, Hammond, Kirsten, Sullivan, Barbara A., He, Xi, Taniuchi, Ichiro, Kappes, Dietmar, Kronenberg, Mitchell
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867285/
https://ncbi.nlm.nih.gov/pubmed/20404101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090557
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