Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function

Patients with Wiskott-Aldrich syndrome (WAS) have numerous immune cell deficiencies, but it remains unclear how abnormalities in individual cell types contribute to the pathologies of WAS. In T cells, the WAS protein (WASp) regulates actin polymerization and transcription, and plays a role in the dy...

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Detalhes bibliográficos
Main Authors: Morales-Tirado, Vanessa, Sojka, Dorothy K., Katzman, Shoshana D., Lazarski, Christopher A., Finkelman, Fred D., Urban, Joseph F., Fowell, Deborah J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867263/
https://ncbi.nlm.nih.gov/pubmed/20032499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-235754
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