Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton

Thiolutin is a dithiole synthesized by Streptomyces sp. that inhibits endothelial cell adhesion and tumor growth. We show here that thiolutin potently inhibits developmental angiogenesis in zebrafish and vascular outgrowth from tissue explants in 3D cultures. Thiolutin is a potent and selective inhi...

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Detalhes bibliográficos
Main Authors: Jia, Yifeng, Wu, Shiaw-Lin, Isenberg, Jeff S., Dai, Shujia, Sipes, John M., Field, Lyndsay, Zeng, Bixi, Bandle, Russell W., Ridnour, Lisa A., Wink, David A., Ramchandran, Ramani, Karger, Barry L., Roberts, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2009
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866983/
https://ncbi.nlm.nih.gov/pubmed/19579057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-009-0130-0
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