Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton

Thiolutin is a dithiole synthesized by Streptomyces sp. that inhibits endothelial cell adhesion and tumor growth. We show here that thiolutin potently inhibits developmental angiogenesis in zebrafish and vascular outgrowth from tissue explants in 3D cultures. Thiolutin is a potent and selective inhi...

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Autori principali: Jia, Yifeng, Wu, Shiaw-Lin, Isenberg, Jeff S., Dai, Shujia, Sipes, John M., Field, Lyndsay, Zeng, Bixi, Bandle, Russell W., Ridnour, Lisa A., Wink, David A., Ramchandran, Ramani, Karger, Barry L., Roberts, David D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2009
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866983/
https://ncbi.nlm.nih.gov/pubmed/19579057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-009-0130-0
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