Cortical binding of Pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease

BACKGROUND: To date, all known Alzheimer's disease genes influence amyloid beta (Aβ). The development of in vivo imaging of Aβ deposition in the human brain using Pittsburgh compound B (PIB) offers the possibility of using cortical PIB binding as a quantitative endophenotype for genetic studies...

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Autores principales: Hinrichs, Anthony L., Mintun, Mark A., Head, Denise, Fagan, Anne M., Holtzman, David M., Morris, John C., Goate, Alison M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866645/
https://ncbi.nlm.nih.gov/pubmed/19892322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.09.012
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