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Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.

The negative factor (nef) of human immunodeficiency virus (HIV) type 1 acts to down-regulate virus replication. To decipher the step in the virus life cycle affected by nef, functional proviral clones with (pHIV F-) or without (pHIV F+) a deletion mutation in the nef gene were constructed. In CD4+ c...

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Detalhes bibliográficos
Main Authors: Niederman, T M, Thielan, B J, Ratner, L
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC286639/
https://ncbi.nlm.nih.gov/pubmed/2784001
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