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Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.

The negative factor (nef) of human immunodeficiency virus (HIV) type 1 acts to down-regulate virus replication. To decipher the step in the virus life cycle affected by nef, functional proviral clones with (pHIV F-) or without (pHIV F+) a deletion mutation in the nef gene were constructed. In CD4+ c...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Niederman, T M, Thielan, B J, Ratner, L
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286639/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784001/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.4.1128
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