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Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.
The negative factor (nef) of human immunodeficiency virus (HIV) type 1 acts to down-regulate virus replication. To decipher the step in the virus life cycle affected by nef, functional proviral clones with (pHIV F-) or without (pHIV F+) a deletion mutation in the nef gene were constructed. In CD4+ c...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1989
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.4.1128 |
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