Identification of a novel set of scaffolding residues that are instrumental for the inhibitory property of Kunitz (STI) inhibitors

For canonical serine protease inhibitors (SPIs), scaffolding spacer residue Asn or Arg religates cleaved scissile peptide bond to offer efficient inhibition. However, several designed “mini-proteins,” containing the inhibitory loop and the spacer(s) with trimmed scaffold behave like substrates, indi...

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Hlavní autoři: Khamrui, Susmita, Majumder, Sudip, Dasgupta, Jhimli, Dattagupta, Jiban K, Sen, Udayaditya
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866283/
https://ncbi.nlm.nih.gov/pubmed/20073082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.338
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