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Identification of a novel set of scaffolding residues that are instrumental for the inhibitory property of Kunitz (STI) inhibitors
For canonical serine protease inhibitors (SPIs), scaffolding spacer residue Asn or Arg religates cleaved scissile peptide bond to offer efficient inhibition. However, several designed “mini-proteins,” containing the inhibitory loop and the spacer(s) with trimmed scaffold behave like substrates, indi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866283/ https://ncbi.nlm.nih.gov/pubmed/20073082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.338 |
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