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Detecting cross-linked peptides by searching against a database of cross-linked peptide pairs

Mass spectrometric identification of cross-linked peptides can provide valuable information about the structure of protein complexes. We describe a straightforward database search scheme that identifies and assigns statistical confidence estimates to spectra from cross-linked peptides. The method is...

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Bibliographic Details
Main Authors: McIlwain, Sean, Singh, Pragya, Draghicescu, Paul, Goodlett, David R., Noble, William Stafford
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866041/
https://ncbi.nlm.nih.gov/pubmed/20349954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr901163d
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