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Matrix Metalloproteinase Inhibition Enhances the Rate of Nerve Regeneration In Vivo by Promoting De-Differentiation and Mitosis of Supporting Schwann Cells

Following peripheral nerve injury, Schwann cells (SCs) vigorously divide to survive and produce a sufficient number of cells to accompany regenerating axons. Matrix metalloproteinases (MMPs) have emerged as modulators of SC signaling and mitosis. Using a 5-bromo-2-deoxyuridine (BrdU) incorporation a...

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Hlavní autoři: Liu, Huaqing, Kim, Youngsoon, Chattopadhyay, Sharmila, Shubayev, Igor, Dolkas, Jennifer, Shubayev, Veronica I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866025/
https://ncbi.nlm.nih.gov/pubmed/20448483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181d68d12
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