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Normal Ciliogenesis Requires Synergy between the Cystic Kidney Disease Genes MKS-3 and NPHP-4

Cilia dysfunction contributes to renal cyst formation in multiple human syndromes including nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), Joubert syndrome (JBTS), and Bardet-Beidl syndrome (BBS). Although genetically heterogeneous, these diseases share several loci that affect cilia and/or...

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Autori principali: Williams, Corey L., Masyukova, Svetlana V., Yoder, Bradley K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865747/
https://ncbi.nlm.nih.gov/pubmed/20150540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009060597
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