A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4

Nephronophthisis (NPHP) is a ciliopathy in which genetic modifiers may underlie the variable penetrance of clinical features. To identify modifiers, a screen was conducted on C. elegans nphp-4(tm925) mutants. Mutations in ten loci exacerbating nphp-4(tm925) ciliary defects were obtained. Four loci h...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Masyukova, Svetlana V., Landis, Dawn E., Henke, Scott J., Williams, Corey L., Pieczynski, Jay N., Roszczynialski, Kelly N., Covington, Jannese E., Malarkey, Erik B., Yoder, Bradley K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749664/
https://ncbi.nlm.nih.gov/pubmed/26863025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005841
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