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Reduced Notch Signaling Leads to Renal Cysts and Papillary Microadenomas

The formation of proximal nephron segments requires canonical Notch2 signaling, but other functions of Notch signaling during renal development are incompletely understood. Here, we report that proximal tubules forming with reduced Notch signaling, resulting from delayed conditional inactivation of...

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Hlavní autoři: Surendran, Kameswaran, Selassie, Meron, Liapis, Helen, Krigman, Hannah, Kopan, Raphael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865744/
https://ncbi.nlm.nih.gov/pubmed/20378824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009090925
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