Common variation in KITLG and at 5q31.3 proximate to SPRY4 predispose to testicular germ cell cancer

Evidence suggests that testicular germ cell tumors (TGCT) have a strong underlying genetic component. We performed a genome-wide scan among 277 TGCT cases and 919 controls. Seven markers at 12p22 within c-KIT ligand (KITLG) reached genome-wide significance (P < 5.0 × 10(−8)). In independent repli...

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Hlavní autoři: Kanetsky, Peter A., Mitra, Nandita, Vardhanabhuti, Saran, Li, Mingyao, Vaughn, David J., Letrero, Richard, Ciosek, Stephanie L., Doody, David R., Smith, Lauren M., Weaver, JoEllen, Albano, Anthony, Chen, Chu, Starr, Jacqueline R., Rader, Daniel J., Godwin, Andrew K., Reilly, Muredach P., Hakonarson, Hakon, Schwartz, Stephen M., Nathanson, Katherine L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865677/
https://ncbi.nlm.nih.gov/pubmed/19483682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.393
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