Common variation in KITLG and at 5q31.3 proximate to SPRY4 predispose to testicular germ cell cancer

Evidence suggests that testicular germ cell tumors (TGCT) have a strong underlying genetic component. We performed a genome-wide scan among 277 TGCT cases and 919 controls. Seven markers at 12p22 within c-KIT ligand (KITLG) reached genome-wide significance (P < 5.0 × 10(−8)). In independent repli...

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Detalhes bibliográficos
Main Authors: Kanetsky, Peter A., Mitra, Nandita, Vardhanabhuti, Saran, Li, Mingyao, Vaughn, David J., Letrero, Richard, Ciosek, Stephanie L., Doody, David R., Smith, Lauren M., Weaver, JoEllen, Albano, Anthony, Chen, Chu, Starr, Jacqueline R., Rader, Daniel J., Godwin, Andrew K., Reilly, Muredach P., Hakonarson, Hakon, Schwartz, Stephen M., Nathanson, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865677/
https://ncbi.nlm.nih.gov/pubmed/19483682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.393
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