Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach are unknown. Here we show that the complete development of protective CD8+ T cell responses requires p...

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Detalhes bibliográficos
Main Authors: Cockburn, Ian A., Chen, Yun-Chi, Overstreet, Michael G., Lees, Jason R., van Rooijen, Nico, Farber, Donna L., Zavala, Fidel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865532/
https://ncbi.nlm.nih.gov/pubmed/20463809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000877
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