Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate

Combinatorial regulation of gene expression is ubiquitous in eukaryotes with multiple inputs converging on regulatory control elements. The dynamic properties of these elements determine the functionality of genetic networks regulating differentiation and development. Here we propose a method to qua...

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Bibliographic Details
Main Authors: Narula, Jatin, Smith, Aileen M., Gottgens, Berthold, Igoshin, Oleg A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865510/
https://ncbi.nlm.nih.gov/pubmed/20463872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000771
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