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Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate

Combinatorial regulation of gene expression is ubiquitous in eukaryotes with multiple inputs converging on regulatory control elements. The dynamic properties of these elements determine the functionality of genetic networks regulating differentiation and development. Here we propose a method to qua...

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Detalhes bibliográficos
Main Authors: Narula, Jatin, Smith, Aileen M., Gottgens, Berthold, Igoshin, Oleg A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865510/
https://ncbi.nlm.nih.gov/pubmed/20463872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000771
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