mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae

DNA polymerase γ (pol γ) is responsible for replication and repair of mitochondrial DNA (mtDNA). Over 150 mutations in POLG (which encodes pol γ) have been discovered in patients with mitochondrial disorders including Alpers, progressive external ophthalmoplegia and ataxia-neuropathy syndrome. Howev...

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Detaylı Bibliyografya
Asıl Yazarlar: Stumpf, Jeffrey D., Bailey, Christopher M., Spell, Diana, Stillwagon, Matthew, Anderson, Karen S., Copeland, William C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2010
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865372/
https://ncbi.nlm.nih.gov/pubmed/20185557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq089
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