Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.

To evaluate the possibility of administering therapeutic proteins via the respiratory route, we administered an aerosol of recombinant DNA-produced human alpha 1-antitrypsin (rAAT) to anesthetized sheep and measured levels of the protein in epithelial lining fluid (ELF), lung lymph, blood, and urine...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Hubbard, R C, Casolaro, M A, Mitchell, M, Sellers, S E, Arabia, F, Matthay, M A, Crystal, R G
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286537/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2783491/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.2.680
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