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Role of Protein Misfolding in DFNA9 Hearing Loss

Mutations in the COCH (coagulation factor C homology) gene have been attributed to DFNA9 (deafness, autosomal-dominant 9), an autosomal-dominant non-syndromic hearing loss disorder. However, the mechanisms responsible for DFNA9 hearing loss remain unknown. Here, we demonstrate that mutant cochlin, t...

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Autors principals: Yao, Jianhua, Py, Bénédicte F., Zhu, Hong, Bao, Jianxin, Yuan, Junying
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865277/
https://ncbi.nlm.nih.gov/pubmed/20228067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106724
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