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The Signal Peptide of the IgE Receptor α-Chain Prevents Surface Expression of an Immunoreceptor Tyrosine-based Activation Motif-free Receptor Pool
The high affinity receptor for IgE, Fc epsilon receptor I (FcϵRI), is an activating immune receptor and key regulator of allergy. Antigen-mediated cross-linking of IgE-loaded FcϵRI α-chains induces cell activation via immunoreceptor tyrosine-based activation motifs in associated signaling subunits,...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865261/ https://ncbi.nlm.nih.gov/pubmed/20304923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104281 |
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