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Hijacking HES1: Tumors Co-opt the Anti-differentiation Strategies of Quiescent Cells
Quiescent cells and tumor cells share the ability to evade irreversible cell fates. It was recently shown that the transcriptional regulator HES1 protects quiescent fibroblasts from differentiation or senescence. HES1 is highly expressed in rhabdomyosarcomas, and inhibition of HES1 restores differen...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864914/ https://ncbi.nlm.nih.gov/pubmed/20022559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2009.11.001 |
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