α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice

The protein transduction domain from human immunodeficiency virus (HIV) Tat allows proteins to penetrate the cell membrane. Enhanced cellular uptake of therapeutic proteins could benefit a number of disorders. This is especially true for lysosomal storage disorders (LSDs) where enzyme replacement th...

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Autori principali: Higuchi, Koji, Yoshimitsu, Makoto, Fan, Xin, Guo, Xiaoxin, Rasaiah, Vanessa I, Yen, Jennifer, Tei, Chuwa, Takenaka, Toshihiro, Medin, Jeffrey A
Natura: Artigo
Lingua:Inglês
Pubblicazione: ScholarOne 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864812/
https://ncbi.nlm.nih.gov/pubmed/20454522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00163
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