α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice

The protein transduction domain from human immunodeficiency virus (HIV) Tat allows proteins to penetrate the cell membrane. Enhanced cellular uptake of therapeutic proteins could benefit a number of disorders. This is especially true for lysosomal storage disorders (LSDs) where enzyme replacement th...

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Main Authors: Higuchi, Koji, Yoshimitsu, Makoto, Fan, Xin, Guo, Xiaoxin, Rasaiah, Vanessa I, Yen, Jennifer, Tei, Chuwa, Takenaka, Toshihiro, Medin, Jeffrey A
格式: Artigo
語言:Inglês
出版: ScholarOne 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864812/
https://ncbi.nlm.nih.gov/pubmed/20454522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00163
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