Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-x(L) by SHP-2 in primary lung endothelial cells

Angiotensin II (Ang II) is a key proapoptotic factor in fibrotic tissue diseases. However, the mechanism of Ang-II-induced cell death in endothelial cells has not been previously elucidated. Using the neutral comet assay and specific receptor antagonists and agonists, we found that Ang-II-mediated a...

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Hauptverfasser: Lee, Young H., Mungunsukh, Ognoon, Tutino, Rebecca L., Marquez, Ana P., Day, Regina M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2010
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864711/
https://ncbi.nlm.nih.gov/pubmed/20406888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.063545
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