Glutaredoxin Regulates Apoptosis in Cardiomyocytes via NFκB Targets Bcl-2 and Bcl-xL: Implications for Cardiac Aging

Cardiomyocyte apoptosis is a well-established contributor to irreversible injury following myocardial infarction (MI). Increased cardiomyocyte apoptosis is associated also with aging in animal models, exacerbated by MI; however, mechanisms for this increased sensitivity to oxidative stress are unkno...

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Main Authors: Gallogly, Molly M., Shelton, Melissa D., Qanungo, Suparna, Pai, Harish V., Starke, David W., Hoppel, Charles L., Lesnefsky, Edward J., Mieyal, John J.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2010
Assuntos:
Original Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864653/
https://ncbi.nlm.nih.gov/pubmed/19938943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.2791
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