Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL

In chronic lymphocytic leukemia (CLL), the lymph node (LN) microenvironment delivers critical survival signals by inducing the expression of anti-apoptotic Bcl-2 members Bcl-XL, Bfl-1, and Mcl-1, resulting in apoptosis blockade. We determined previously that resistance against various drugs, among w...

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Publicado en:Cell Death Differ
Autores principales: Haselager, Marco, Thijssen, Rachel, West, Christopher, Young, Louise, Van Kampen, Roel, Willmore, Elaine, Mackay, Simon, Kater, Arnon, Eldering, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167103/
https://ncbi.nlm.nih.gov/pubmed/33495554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00692-w
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