Cloned diphtheria toxin within the periplasm of Escherichia coli causes lethal membrane damage at low pH.
Acidic pH within endosomal vesicles of sensitive animal cells triggers a conformational change in diphtheria toxin (DT) that is believed to cause the B chain to insert into the vesicular membrane and the enzymic A chain to be released into the cytosol. In artificial lipid bilayers, DT forms ion-cond...
Salvato in:
| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1989
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2643104/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.343 |
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