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Cloned diphtheria toxin within the periplasm of Escherichia coli causes lethal membrane damage at low pH.

Acidic pH within endosomal vesicles of sensitive animal cells triggers a conformational change in diphtheria toxin (DT) that is believed to cause the B chain to insert into the vesicular membrane and the enzymic A chain to be released into the cytosol. In artificial lipid bilayers, DT forms ion-cond...

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Autors principals: O'Keefe, D, Collier, R J
Format: Artigo
Idioma:Inglês
Publicat: 1989
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC286461/
https://ncbi.nlm.nih.gov/pubmed/2643104
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