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Structural and Biophysical Studies of Human PARP-1 in Complex with Damaged DNA
The enzyme Poly (ADP-Ribose) polymerase-1 (PARP-1) is a global monitor of chromatin structure and DNA damage repair. PARP-1 binds to nucleosomes and poly (ADP-ribosylates) histones and several chromatin-associated factors to expose specific DNA sequences to the cellular machinery involved in gene tr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864582/ https://ncbi.nlm.nih.gov/pubmed/19962992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.062 |
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