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Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis.

C5a is an inflammatory mediator potentially involved in a number of diseases. To help define which of its 74 residues are important for receptor binding and response triggering, changes in the amino acid sequence of C5a were introduced by site-directed mutagenesis. Synthetic C5a-encoding genes incor...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mollison, K W, Mandecki, W, Zuiderweg, E R, Fayer, L, Fey, T A, Krause, R A, Conway, R G, Miller, L, Edalji, R P, Shallcross, M A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286450/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2643101/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.292
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