Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis.

C5a is an inflammatory mediator potentially involved in a number of diseases. To help define which of its 74 residues are important for receptor binding and response triggering, changes in the amino acid sequence of C5a were introduced by site-directed mutagenesis. Synthetic C5a-encoding genes incor...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Mollison, K W, Mandecki, W, Zuiderweg, E R, Fayer, L, Fey, T A, Krause, R A, Conway, R G, Miller, L, Edalji, R P, Shallcross, M A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1989
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286450/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2643101/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.292
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