Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes.

Seven morphologically nontransformed (flat) revertants with reduced tumorigenicity in vivo have been isolated from populations of Kirsten sarcoma virus-transformed NIH 3T3 cells transfected with a cDNA expression library of normal human fibroblasts. Each revertant harbors 1-10 recombinant plasmids p...

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Main Authors: Noda, M, Kitayama, H, Matsuzaki, T, Sugimoto, Y, Okayama, H, Bassin, R H, Ikawa, Y
Formato: Artigo
Idioma:Inglês
Publicado: 1989
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC286424/
https://ncbi.nlm.nih.gov/pubmed/2463620
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