Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity

BACKGROUND: The transition from premalignant to invasive tumour growth is a prolonged multistep process governed by phenotypic adaptation to changing microenvironmental selection pressures. Cancer prevention strategies are required to interrupt or delay somatic evolution of the malignant invasive ph...

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Main Authors: Smallbone, Kieran, Maini, Philip K, Gatenby, Robert A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864239/
https://ncbi.nlm.nih.gov/pubmed/20406440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-5-22
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