The Signal Transducer STAT5 Inhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8

The development of distinct dendritic cell (DC) subsets is regulated by cytokines. Flt3-ligand- (Flt3L) is necessary for plasmacytoid (pDC) and conventional DC (cDC) maturation. GM-CSF inhibits Flt3L-driven pDC production while promoting cDC growth. We show that GM-CSF selectively utilizes STAT5 to...

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Bibliografiske detaljer
Main Authors: Esashi, Eiji, Wang, Yui-Hsi, Perng, Olivia, Qin, Xiao-Feng, Liu, Yong-Jun, Watowich, Stephanie S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864148/
https://ncbi.nlm.nih.gov/pubmed/18342552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.02.013
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