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Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Human neutrophil elastase (HNE) has been implicated as a major contributor to tissue destruction in various disease states, including emphysema. The structure of HNE, at neutral pH, in complex with methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone (MSACK), has been solved and refined to an R facto...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Navia, M A, McKeever, B M, Springer, J P, Lin, T Y, Williams, H R, Fluder, E M, Dorn, C P, Hoogsteen, K
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
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Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286392/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2911584/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.7
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