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Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Human neutrophil elastase (HNE) has been implicated as a major contributor to tissue destruction in various disease states, including emphysema. The structure of HNE, at neutral pH, in complex with methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone (MSACK), has been solved and refined to an R facto...

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Detalhes bibliográficos
Main Authors: Navia, M A, McKeever, B M, Springer, J P, Lin, T Y, Williams, H R, Fluder, E M, Dorn, C P, Hoogsteen, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC286392/
https://ncbi.nlm.nih.gov/pubmed/2911584
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