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Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin

A new class of N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide inhibitors of influenza virus hemagglutinin (HA)-mediated membrane fusion that has a narrow and defined structure-activity relationship was identified. In Madin-Darby canine kidney (MDCK) cells infected with different strains of human in...

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書誌詳細
主要な著者: Vanderlinden, Evelien, Göktaş, Fusun, Cesur, Zafer, Froeyen, Matheus, Reed, Mark L., Russell, Charles J., Cesur, Nesrin, Naesens, Lieve
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863778/
https://ncbi.nlm.nih.gov/pubmed/20181685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02325-09
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