Two N-Linked Glycosylation Sites in the V2 and C2 Regions of Human Immunodeficiency Virus Type 1 CRF01_AE Envelope Glycoprotein gp120 Regulate Viral Neutralization Susceptibility to the Human Monoclonal Antibody Specific for the CD4 Binding Domain

A recombinant human monoclonal antibody, IgG1 b12 (b12), recognizes a conformational epitope on human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) gp120 that overlaps the CD4 binding domain. Although b12 is able to broadly neutralize HIV-1 subtype B, C, and D viruses, many HIV-1...

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Bibliographic Details
Main Authors: Utachee, Piraporn, Nakamura, Shota, Isarangkura-na-ayuthaya, Panasda, Tokunaga, Kenzo, Sawanpanyalert, Pathom, Ikuta, Kazuyoshi, Auwanit, Wattana, Kameoka, Masanori
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863754/
https://ncbi.nlm.nih.gov/pubmed/20164234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02619-09
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