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Mechanism of the Synergistic Effect of Amiodarone and Fluconazole in Candida albicans
The antiarrhythmic drug amiodarone has been found to have fungicidal activity. In Saccharomyces cerevisiae, its antifungal activity is mediated by calcium overload stress, which leads to a rapid nuclear accumulation of the calcineurin-regulated transcription factor CRZ1. In addition, low doses of am...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863688/ https://ncbi.nlm.nih.gov/pubmed/20194694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01728-09 |
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