Crystal Structure of the Narrow-Spectrum OXA-46 Class D β-Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates

Class D β-lactamases represent a heterogeneous group of active-site serine β-lactamases that show an extraordinary panel of functional features and substrate profiles, thus representing relevant models for biochemical and structural studies. OXA-46 is a narrow-spectrum enzyme belonging to the OXA-2...

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Autores principales: Docquier, Jean-Denis, Benvenuti, Manuela, Calderone, Vito, Giuliani, Francesco, Kapetis, Dimos, De Luca, Filomena, Rossolini, Gian Maria, Mangani, Stefano
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863608/
https://ncbi.nlm.nih.gov/pubmed/20145076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01517-09
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