Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design

Class D β-lactamases with carbapenemase activity are emerging as carbapenem-resistance determinants in Gram-negative bacterial pathogens, mostly Acinetobacter baumannii and Klebsiella pneumoniae. Carbapenemase activity is an unusual feature among class D β-lactamases, and the structural elements res...

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Detalhes bibliográficos
Main Authors: De Luca, Filomena, Benvenuti, Manuela, Carboni, Filippo, Pozzi, Cecilia, Rossolini, Gian Maria, Mangani, Stefano, Docquier, Jean-Denis
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215043/
https://ncbi.nlm.nih.gov/pubmed/22042844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110530108
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