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Kinetic Characterization of the WalRK(Spn) (VicRK) Two-Component System of Streptococcus pneumoniae: Dependence of WalK(Spn) (VicK) Phosphatase Activity on Its PAS Domain

The WalRK two-component system plays important roles in maintaining cell wall homeostasis and responding to antibiotic stress in low-GC Gram-positive bacteria. In the major human pathogen, Streptococcus pneumoniae, phosphorylated WalR(Spn) (VicR) response regulator positively controls the transcript...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gutu, Alina D., Wayne, Kyle J., Sham, Lok-To, Winkler, Malcolm E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863487/
https://ncbi.nlm.nih.gov/pubmed/20190050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01690-09
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