The Nonmevalonate Pathway of Isoprenoid Biosynthesis in Mycobacterium tuberculosis Is Essential and Transcriptionally Regulated by Dxs

Mycobacterium tuberculosis synthesizes isoprenoids via the nonmevalonate or DOXP pathway. Previous work demonstrated that three enzymes in the pathway (Dxr, IspD, and IspF) are all required for growth in vitro. We demonstrate the essentiality of the key genes dxs1 and gcpE, confirming that the pathw...

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Bibliographic Details
Main Authors: Brown, Amanda C., Eberl, Matthias, Crick, Dean C., Jomaa, Hassan, Parish, Tanya
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863480/
https://ncbi.nlm.nih.gov/pubmed/20172995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01402-09
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