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Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhi...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409342/ https://ncbi.nlm.nih.gov/pubmed/18489786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-8-78 |
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