Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers

BACKGROUND: Alcohol and tobacco dependence are highly comorbid disorders, with preclinical evidence suggesting a role for nicotinic acetylcholine receptors (nAChRs) in alcohol consumption. Varenicline, a partial nicotinic agonist with high affinity for the α4β2 nAChR receptor, reduced ethanol intake...

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Main Authors: McKee, Sherry A., Harrison, Emily L.R., O’Malley, Stephanie S., Krishnan-Sarin, Suchitra, Shi, Julia, Tetrault, Jeanette M., Picciotto, Marina R., Petrakis, Ismene L., Estevez, Naralys, Balchunas, Erika
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863311/
https://ncbi.nlm.nih.gov/pubmed/19249750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.01.029
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