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p35 Is Required for CDK5 Activation in Cellular Senescence
The retinoblastoma tumor suppressor gene (RB-1) is a key regulator of cellular senescence. Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in senescence-like changes. The induction of the senescent phenotype by pRB requires the postmitotic kinase CDK5, the be...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863219/ https://ncbi.nlm.nih.gov/pubmed/20181942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.066118 |
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